Multiplication of Toxoplasma gondii in maturing erythroid cells.
نویسندگان
چکیده
Multiplication of Toxoplasma gondii was examined in vitro in murine erythroid cells at different stages of development. Toxoplasma gondii multiplied in nucleated erythroblasts and enucleated reticulocytes from the foetal liver, and in immature reticulocytes and yolk-sac derived erythrocytes from the foetal circulation. However, the rate of multiplication was lowered as erythroblasts matured, and multiplication was not detected in foetal erythrocytes. A decrease in the multiplication rate with maturation was also observed with yolk-sac erythrocytes.
منابع مشابه
Inhibition of multiplication of Toxoplasma gondii by human monocytes exposed to T-lymphocyte products
The multiplication of Toxoplasma gondii was quantitated in human monocytes in vitro by phase-contrast microscopy. Toxoplasma multiplication was identical in monocytes from subjects byt was significantly inhibited in cells from both sources if the monocytes were preincubated with immune lymphocytes and toxoplasma monocytes were preincubated with immune lymphocytes and toxoplasma antigen. Superna...
متن کاملEffect of hydroxyurea on the intracellular multiplication of Toxoplasma gondii, Leishmania amazonensis and Trypanosoma cruzi.
Toxoplasma gondii, Leishmania amazonensis and Trypanosoma cruzi are obligate intracellular parasites that multiply until lysis of host cells. The present study was undertaken to evaluate the effect of hydroxyurea (an inhibitor of cell division at the G1/S phase) on the multiplication of L. amazonensis, T. gondii, and T. cruzi in infected host cells. Infected cells were treated with hydroxyurea ...
متن کاملIn vitro multiplication of Toxoplasma gondii and Trypanosoma cruzi in mouse, rat, and hamster astrocytes.
The infection and multiplication of Toxoplasma gondii and Trypanosoma cruzi were compared in primary cultures of white rat, mouse and hamster astrocytes. These cells were cultured on cover slides and infected with T. gondii tachyzoites or T. cruzi blood trypomastigotes. Results show that hamster astrocytes are more susceptible to the multiplication of both parasites than rat and mouse cells. Th...
متن کاملAn in vitro study on the toxoplasmacidal activity of lonomycin A in host cells.
Lonomycin A at various concentrations was tested for its inhibitory effect on Toxoplasma multiplication in host cells cultured in vitro. Results indicate that lonomycin A at a concentration of 0.01 micrograms per ml in TC-199 medium demonstrated a high degree of antitoxoplasma activity with complete inhibition of Toxoplasma multiplication in the host cells. Lymphokines, a supernatant produced f...
متن کاملToxoplasma gondii in vitro cultivation: propagation
Based on a serum-free and CO,-independent culture of Toxoplasma gondii in vitro, a long-term propagation of a highly virulent strain of this parasite was developed. Toxoplasma monolayer cultures were fed on a weekly cycle with native host cells (HEp-2) while changing the medium, thus simultaneously removing cell debris and just bred trophozoites. Establishing this method was of low effort in or...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of general microbiology
دوره 118 1 شماره
صفحات -
تاریخ انتشار 1980